Started in 1982, DEPCO (Dependable Education Products Company) was introduced as a manufacturers' representative organization, which represented manufacturers of vocational education products. Seeing that there were gaps in the technology education market, DEPCO introduced its own curriculum in 1991, blending careers and technology. Through the years, DEPCO has introduced new curriculum centered around science; business, marketing, and information technology (IT); careers and technology; family and consumer sciences (FACS); manufacturing; and pre-engineering.
In the fall of 2010, DEPCO began exclusively marketing Applied Technologies' health science products including Career Pathways and Health Science Foundations in the continental US. In 2012, DEPCO acquired Applied Technologies' health product line and updated the product to utilize DEPCO's lab management and content delivery system, DEPCO Studio.